Keywords: Machine Learning/Artificial Intelligence, Machine Learning/Artificial IntelligenceWe developed a Transformer-based deep learning denoising model to improve the SNR for both single and multi-delay perfusion images acquired using 3D pseudo-continuous arterial spin labeling (pCASL). This method can significantly improve SNR (~2-fold) of the perfusion images without introducing bias for CBF and ATT quantification for both single-delay and multi-delay 3D pCASL. Further training and testing of this model on clinical datasets acquired on different vendor platforms is warranted.
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