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Abstract #2903

Deep Learning-denoised Isotropic 2mm Whole Brain pseudo-Continuous Arterial Spin Labeling at 7T

Chenyang Zhao1, Qinyang Shou1, Xingfeng Shao1, and Danny JJ Wang1,2
1Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States

Synopsis

Keywords: Machine Learning/Artificial Intelligence, Arterial spin labelling, Noise reductionOptimized pseudo-Continuous Arterial Spin Labeling has been implemented at 7T. To achieve whole brain high-resolution (2mm isotropic) perfusion imaging at 7T, however, requires prolonged scan time with an increased number of segments. A deep learning (DL) model was trained to boost the signal-to-noise ratio (SNR) for a scan with fewer repetitions and thus a shorter scan time. The analysis of SNR and temporal SNR suggests that at least 3 repetitions are needed to make a high-SNR prediction comparable to the full scan without compromising quantification accuracy. With DL denoising, the original 12 mins scan can be finished in 4 min.

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