Abstract #2910

Combined Parkinson’s Disease Related Patterns using ASL MRI and FDG PET

Yu Zeng¹, Zizhao Ju², Weiying Dai³, Yong Zhang⁴, David Alsop⁵, Chuantao Zuo², and Li Zhao¹

¹College of Biomedical Engineering & Instrument Science, Zhejiang University, Zhejiang, China, ²PET Center & National Center for Neurological Disorders & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China, ³Department of Computer Science, State University of New York at Binghamton, Binghamton, NY, United States, ⁴GE Healthcare, Shanghai, China, ⁵Radiology, Beth Israel Deaconess Medical Center and Harvard Medical school,, Bostom, MA, United States

Synopsis

Keywords: Data Analysis, Parkinson's Disease, Parkinson's disease-related pattern (PDRP), multimodalityParkinson's disease-related patterns (PDRPs) of metabolism and perfusion have been reported to reflect brain abnormalities in Parkinson’s disease (PD). However, differences between the glucose metabolism PDRP derived using FDG-PET and the perfusion PDRP derived using ASL have not been compared directly in the same patient cohort. In this work, PDRPs were compared using PET and ASL images of 43 PD patients and 28 health controls using Scaled Subprofile Model analysis. In addition, a new method was proposed to build a multi-modality pattern. Our primary results showed that combined metabolism-perfusion PDRP resulted in superior accuracy than ASL- and PET-derived PDRP alone.

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