Abstract #2912

MT-DICE for Simultaneous Quantification of Perfusion, Permeability, and Susceptibility

Yang Chen^1,2, Zhehao Hu¹, Jiayu Xiao¹, Mark Shiroishi¹, Wensha Yang¹, Debiao Li³, Anthony G. Christodoulou³, and Zhaoyang Fan¹

¹Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ³Cedars-Sinai Medical Center, Los Angeles, CA, United States

Synopsis

Keywords: Quantitative Imaging, Permeability, perfusion, susceptibilityWe have recently developed an MR MultiTasking based Dynamic Imaging for Cerebrovascular Evaluation (MT-DICE) technique that provides DCE- and leakage-corrected DSC-MRI parameters simultaneously with one scan and a single-dose contrast injection. This work further expanded the technique by incorporating quantitative susceptibility mapping. The refined technique was validated in healthy volunteers and patients, demonstrating the good agreement with reference methods.

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