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Abstract #2915

3D Artificial Cerebral Blood Volume Generation from T1W Structural MRI

Vishwanatha Mitnala Rao1, Scott A Small2, and Jia Guo3
1Biomedical Engineering, Columbia University, Acton, MA, United States, MA, United States, 2Department of Neurology, Columbia University Medical Center, New York, NY, United States, 3Department of Psychiatry, Columbia University, New York, NY, United States

Synopsis

Keywords: Machine Learning/Artificial Intelligence, BrainWhile gadolinium-based contrast agents are necessary to generate a quantitative mapping of brain metabolism, they are invasive with unclear long-term side-effects. As such, convolutional neural networks (CNNs) have been explored as a method to generate artificial cerebral blood volume (aCBV) maps from T1W structural MRI scans. However, prior implementations process MRI in 2D slices, severely limiting output resolution, production time, and utility. In this study, we propose a 3D CNN-Transformer hybrid aCBV generation tool that outperforms both 2D and 3D implementations of the prior state-of-the-art model (PSNR: 29.46, P.R.: 0.836, SSIM: 0.875, S.R.: 0.681).

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Keywords