Abstract #2918

MRI evidence for reduced human brain oxygen metabolism during midazolam sedation

Hannah L Chandler¹, Ian Driver², Sharmila Khot¹, Zoltán Auer³, Murthy Varanasi³, Neeraj Saxena^1,3, Michael Germuska², and Richard G Wise^1,4,5

¹Cardiff University Brain Research Imaging Centre (CUBRIC), Department of Psychology, Cardiff University, Cardiff, United Kingdom, ²Cardiff University Brain Research Imaging Centre (CUBRIC), School of Physics and Astronomy, Cardiff University, Cardiff, United Kingdom, ³Department of Anaesthetics, ICU and Pain medicine, Cwm Taf Morgannwg University Health Board, Merthyr Tydfil, United Kingdom, ⁴Neurosciences, Imaging and Clinical Sciences, University “G. d'Annunzio” of Chieti-Pescara, Chieti, Italy, ⁵Institute for Advanced Biomedical Technologies (ITAB), G. d’Annunzio University’ of Chieti-Pescara, Chieti, Italy

Synopsis

Keywords: Data Analysis, Arterial spin labellingWe investigated the effects of mild sedation with the type A GABA receptor positive allosteric modulator (GABA_A-R PAM) midazolam, on cerebral blood flow (CBF), oxygen extraction fraction (OEF) and the rate of cerebral metabolic oxygen consumption (CMRO₂) in the healthy human brain using ASL and TRUST MRI. CMRO₂ was significantly reduced during sedation compared to wakefulness but no statistically significant change in CBF or OEF was detected. Our data are consistent with prior imaging evidence of reduced brain energy consumption during sedation with midazolam.

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