Abstract #2944

Association of neuroanatomical changes with neuropsychological changes in Treated Adult HIV-Positive Patients

Ajin Joy¹, Rajakumar Nagarajan¹, Eric Daar^2,3, Jhelum Paul¹, Santosh K Yadav⁴, Mario Guerrera², Paul M. Macey⁵, and M. Albert Thomas¹

¹Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ²Division of HIV Medicine, Lundquist Institute at Harbor-UCLA Medical Center, Los Angeles, CA, United States, ³Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ⁴Department of Radiology and Radiological Science, School of Medicine,, Johns Hopkins University, Baltimore, MD, United States, ⁵School of Nursing and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, United States

Synopsis

Keywords: Data Processing, BrainThis study was designed to use the structural MRI data to characterize volumetric changes in gray matter and white matter, and to determine variations in cortical thickness, in a group of HIV-infected individuals to understand how their brain structural changes are associated with their neuropsychological state compared to a group of healthy individuals with similar social, behavioral backgrounds. Despite the demographic similarities and cART, we observed reduced gray and white matter volumes, as well as altered cortical thickness in HIV-infected participants compared with healthy controls. In addition, the neuroanatomic changes in HIV-infected patients showed statistically significant correlations with memory scores.

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