Abstract #2966

A two-perfusion IVIM model to account for both villous and trophoblast perfusion in the human placenta

Alessandra Maiuro^1,2, Giada Ercolani³, Maria Grazia Porpora⁴, Carlo Catalano³, Lucia Manganaro³, and Silvia Capuani^1,2

¹Physics, CNR Institute for Complex Systems (ISC), Rome, Italy, ²Physics, Sapienza University of Rome, Rome, Italy, ³Radiological, Oncological and Pathological Sciences, Umberto I Hospital, Sapienza University of Rome, Rome, Italy, ⁴Maternal and Child Health and Urological Sciences, Umberto I Hospital, Sapienza University of Rome, Rome, Italy

Synopsis

Keywords: Placenta, Diffusion/other diffusion imaging techniques, IVIM, two-perfusion, villi, trophoblastsThe placenta may incur several pathologies during fetal growth due to perfusion impairment such as Fetal-Growth-Restriction (FGR) and the accretism. Two-perfusion IVIM model (with f₁, D₁*, f₂, D*₂ and D parameters) and IVIM model were used to fit data. DWIs were corrected for distributed noise χ. Mean-values differences of the quantified parameters in diseased and healthy placentas were analyzed by ANOVA test. The slower f₂ perfusion fraction associated with trophoblastic perfusion was significantly lower in FGR compared to normal placenta, whereas the faster f₁, quantifying villi perfusion fraction, was higher in the accretism compared to healthy placenta zone.

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