Abstract #2968

Vascular Assessment of Rhesus Macaque Placental Injury through Maternal Intervillous Blood Volume Measurement

Ruiming Chen¹, Logan T. Keding^2,3, Jessica Vazquez^2,3, Kathleen Antony⁴, Heather A. Simmons^2,3, Kevin M. Johnson^1,5,6, Aleksandar K. Stanic⁴, Ruo-Yu Liu¹, Dinesh M. Shah⁴, Thaddus G. Golos^2,3,4, and Oliver Wieben^1,5,6

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Wisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, United States, ³Comparative Biosciences, University of Wisconsin - Madison, Madison, WI, United States, ⁴Obstetrics & Gynecology, University of Wisconsin - Madison, Madison, WI, United States, ⁵Radiology, University of Wisconsin - Madison, Madison, WI, United States, ⁶Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States

Synopsis

Keywords: Placenta, Quantitative ImagingEarly assessment of utero-placental vasculature is an important novel approach to predicting pregnancy outcomes and fetal growth. Ferumoxytol-enhanced MRI is a powerful tool to measure intervillous fractional blood volume (FBV) in vivo, which could reflect structural and vascular health in the placenta. This study reports such measurements for rhesus macaque placentas that underwent localized Tisseel injections to mimic the effects of local ischemia. We observed increased regions of low FBV with gestation following the Tisseel injection.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.