Abstract #2971

Quantitative Placental R2* Mapping on Rhesus Macaques with Ischemic Injury Model

Ruo-Yu Liu¹, Logan T. Keding^2,3, Jessica Vazquez^2,3, Jitka Starekova⁴, Ante Zhu^4,5, Ruiming Chen¹, Kathleen M. Antony⁶, Heather A. Simmons^2,3, Aleksandar K. Stanic⁶, Diego Hernando^1,4, Dinesh M. Shah⁶, Thaddeus G. Golos^2,3,6, and Oliver Wieben^1,4,5

¹Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, United States, ³Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, United States, ⁴Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁵Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁶Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Placenta, Quantitative Imaging, R2* mappingPlacental R2* mapping is a non-invasive, quantitative biomarker with the potential to identify deficiency in uteroplacental oxygenation and blood flow, which would be of significant value in predicting and monitoring pregnancy complications. We introduce a novel thrombotic placental injury model and report mean values, histograms, and spatial distribution of baseline R2* at different gestational ages in healthy and ischemic rhesus macaque placenta based on blood oxygenation level dependent (BOLD) MR imaging. Higher increases in mean values and different spatial patterns of R2* are observed in placenta with induced ischemia.

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