Abstract #2978

Test-retest repeatability of motility MRI in healthy volunteers and patients with Crohn’s disease

Octavia Bane^1,2, David Bennett³, Emre Altinmakas¹, Ghadi Abboud¹, Amine Geahchan¹, Jordan Cuevas^1,2, Alex Menys⁴, Ryan Ungaro⁵, Jean-Frederic Colombel⁵, and Bachir Taouli^1,2

¹Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Takeda Pharmaceuticals, Cambridge, MA, United States, ⁴Motilent Ltd, London, United Kingdom, ⁵Department of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

Synopsis

Keywords: Digestive, Quantitative Imaging, bowel, Crohn's diseaseOur study aims to determine test-retest repeatability in motility (bowel wall motion) index derived from CINE-MRI measured in involved and uninvolved small bowel in patients with Crohn’s disease and in healthy volunteers, to determine a clinically significant threshold of motility change in response to treatment.Motility was lower in the involved areas compared to uninvolved small bowel, and in the uninvolved small bowel ofpatients compared to that of healthy volunteers. We found moderate test-retest repeatability in the motility index of involved bowel (provide average CV) and in the ratio ofmotility indices in involved small bowel and in uninvolved small bowel.

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