Abstract #2980

Dynamic Glucose Enhanced MRI of Brain Tumors using Direct Water Saturation

Peter van Zijl¹, Nirbhay Yadav², Sajad Mohammed Ali³, Anina Seidemo³, David Olayinka Kamson⁴, Lindsay Blair⁵, John Laterra⁶, and Linda Knutsson⁷

¹Radiology, F.M. Kirby Research Center, Johns Hopkins University, Kennedy Krieger Institute, Baltimore, MD, United States, ²Radiology/F.M. Kirby Research Center, Johns Hopkins University, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Medical Radiation Physics, Lund University, Lund, Sweden, ⁴Department of Oncology, Johns Hopkins University, Baltimore, MD, United States, ⁵Neurology, Johns Hopkins University, Baltimore, MD, United States, ⁶Neurology, Johns Hopkins University, Kennedy Krieger Institute, Baltimore, MD, United States, ⁷F.M. Kirby Research Center, Radiology, Medical Radiation Physics, Kennedy Krieger Institute, Johns Hopkins University, Lund University, Baltimore, MD, United States

Synopsis

Keywords: CEST & MT, Cancer, Glucose

The transverse relaxation time (T₂) of water is affected by the presence of exchangeable protons that are chemically shifted with respect to the water protons. We use direct saturation (DS) MRI to dynamically measure this effect during infusion of D-glucose to assess its uptake in brain tumors. The change in T₂ becomes apparent as a line broadening of the DS spectrum, which is acquired using a whole-brain water saturation shift reference (WASSR) acquisition. First results using 0.5g/kg D-glucose show linewidth changes on the order of a few Hertz in glioma patients, allowing separation of tumor tissue from healthy brain tissue.

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