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Abstract #2980

Dynamic Glucose Enhanced MRI of Brain Tumors using Direct Water Saturation

Peter van Zijl1, Nirbhay Yadav2, Sajad Mohammed Ali3, Anina Seidemo3, David Olayinka Kamson4, Lindsay Blair5, John Laterra6, and Linda Knutsson7
1Radiology, F.M. Kirby Research Center, Johns Hopkins University, Kennedy Krieger Institute, Baltimore, MD, United States, 2Radiology/F.M. Kirby Research Center, Johns Hopkins University, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Medical Radiation Physics, Lund University, Lund, Sweden, 4Department of Oncology, Johns Hopkins University, Baltimore, MD, United States, 5Neurology, Johns Hopkins University, Baltimore, MD, United States, 6Neurology, Johns Hopkins University, Kennedy Krieger Institute, Baltimore, MD, United States, 7F.M. Kirby Research Center, Radiology, Medical Radiation Physics, Kennedy Krieger Institute, Johns Hopkins University, Lund University, Baltimore, MD, United States

Synopsis

Keywords: CEST & MT, Cancer, Glucose

The transverse relaxation time (T2) of water is affected by the presence of exchangeable protons that are chemically shifted with respect to the water protons. We use direct saturation (DS) MRI to dynamically measure this effect during infusion of D-glucose to assess its uptake in brain tumors. The change in T2 becomes apparent as a line broadening of the DS spectrum, which is acquired using a whole-brain water saturation shift reference (WASSR) acquisition. First results using 0.5g/kg D-glucose show linewidth changes on the order of a few Hertz in glioma patients, allowing separation of tumor tissue from healthy brain tissue.

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