Abstract #2982

Evaluation of Biological Metabolic Activity within an Atherosclerotic Plaque using Chemical Exchange Saturation Transfer Imaging

Yuki Kanazawa¹, Tosiaki Miyati², Masafumi Harada¹, Mitsuharu Miyoshi³, Yuki Matsumoto¹, Hiroaki Hayashi², Yasuhisa Kanematsu¹, and Yasushi Takagi¹

¹Tokushima University, Tokushima, Japan, ²Kanazawa University, Kanazawa, Japan, ³Global MR Applications and Workflow, GE Healthcare Japan, Hino, Japan

Synopsis

Keywords: CEST & MT, AtherosclerosisWe demonstrated biological metabolic activity within an atherosclerotic plaque of the carotid artery using CEST imaging. 35 patients with carotid stenosis, of which all were pathologically diagnosed with carotid endarterectomy, were evaluated. The following estimation parameters in CEST image were evaluated; bulk water, magnetization transfer, amide proton transfer (APT), and nuclear Overhauser effect (NOE). As a result, there were weak positive correlations between T₁w-signal-ratio and the above-mentioned parameters: bulk water (R = 0.37), APT (R = 0.39), and NOE (R = 0.37). Multi-parametric analysis of CEST imaging can obtain detailed information concerning the activity in an atherosclerotic plaque.

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