Abstract #2987
Metabolic Imaging of malignant gliomas during immunotherapeutic intervention using chemical exchange saturation transfer (CEST) MRI at 9.4T
Kianush Karimian-Jazi1,2, Volker Sturm1, Katharina Schregel1,2, Jessica Hunger1,3, Verena Turco3,4, Noah Enbergs1, Berin Boztepe1,3, Manuel Fischer1, Yannik Streibel1, Nikolaus von Knebel-Doeberitz5, Andreas Korzowski6, Steffen Görke6, Florian Kroh6, Mark E. Ladd6, Heinz-Peter Schlemmer5, Daniel Paech5,7, Christopher B. Rodell8, Michael Platten3,4, Wolfgang Wick2,9, Sabine Heiland1, Martin Bendszus1, and Michael O. Breckwoldt1,3
1Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany, 2Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DTK) within the German Cancer Research Center (DKFZ), Heidelberg, Germany, 3Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DTK) within the German Cancer Research Center (DKFZ), Heidelberg, Germany, 4Department of Neurology, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany, 5Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 6Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 7Clinic for Neuroradiology, University Hospital Bonn, Bonn, Germany, 8School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, United States, 9Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany
Synopsis
Keywords: CEST & MT, High-Field MRI, Glioma
CDNP-R848, an experimental immunotherapeutic TLR7/8 agonist, showed high treatment efficacy with a significant tumor volume reduction and led to a re-normalization of the metabolic properties (MTRex Amide, MTRex Amine and MTRex NOE) of the tumor in relation to the healthy brain, with distinct differences to vehicle treatment. The clinical relevance of CEST imaging appears to be localizing active tumor areas and a better understanding of tumor heterogeneity. In the future, we aim to better characterize the origin of the CEST contrast by correlated histological and spatial metabolic analysis.
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