Abstract #2989

Z-spectral fitting for fat-correction of APT/CEST-MRI including fat-suppression pulses to improve body applications

Jochen Keupp¹, Ivan E. Dimitrov^2,3, Holger Eggers¹, and Elena Vinogradov^3,4

¹Philips Research, Hamburg, Germany, ²Philips Healthcare, Gainesville, FL, United States, ³Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁴Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: CEST & MT, Fat, Z-spectral fitting, Fat suppression pulses

Fat signal correction remains a challenge in APT/CEST-MRI for body-oncology. We show that signal background models that include direct water saturation, MT-effect, and modified fat spectra can be fitted to Z-spectra acquired with/without fat-suppression. APT/CEST signals are then extracted as the residual from the background fit (APT#). The model for fat-suppressed spectra uses a mirrored fat contribution. After B₀-correction, 5 model parameters are sufficient. This allows for the acquisition of clinically feasible protocols using less than 20 Z-spectral offsets. Fat-suppression potentially increases the precision of APT# imaging by lowering the initial fat contribution.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.