Abstract #2994

CEST effect of dimethyl sulfoxide (DMSO) at negative offset frequency

Haoyun Su^1,2, Jianpan Huang¹, and Kannie W.Y. Chan^1,2,3,4,5

¹Department of Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong, ²Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), New Territories, Hong Kong, ³Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴City University of Hong Kong Shenzhen Research Institute, Shenzhen, China, ⁵Tung Biomedical Sciences Centre, City University of Hong Kong, Kowloon, Hong Kong

Synopsis

Keywords: CEST & MT, Molecular ImagingCEST MRI can detect mM range of endogenous and exogenous molecules, and bound small molecules such as glycogen and lactate via rNOE. Here we reported for the first time that DMSO and its structural analogs in aqueous solution had distinctive CEST peaks at the negative offsets of Z-spectrum. CEST effect of DMSO was dependent on saturation power and concentration, and less sensitive to tested temperature. Alcohols, acetone, acetonitrile, acetic acid and N,N-dimethylformamide also showed observable CEST peaks at the negative offsets. Interaction between DMSO and water molecule, such as hydrogen bonding, could contribute to the observed CEST effect.

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