Abstract #2996

Imaging treatment efficacy of repeated photodynamic therapy in glioblastoma using CEST MRI

Vivian W.M. Leung¹, Joseph H.C. Lai¹, Zilin Chen¹, Jianpan Huang¹, Se Weon Park^1,2, Yang Liu^1,2, Charles Hu³, and Kannie W. Y. Chan^1,2,4,5,6

¹Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China, ²Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong, China, ³Incando Therapeutics Pte Ltd, Singapore, Singapore, ⁴Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵City University of Hong Kong Shenzhen Research Institute, Shenzhen, China, ⁶Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong, China

Synopsis

Keywords: CEST & MT, Tumor

Glioblastoma (GBM) is hard to treat and has poor prognosis. Photodynamic therapy (PDT) is a promising treatment for GBM. Here, we detect the treatment efficacies of different PDT schemes (repeated (re-) and single (s-) PDT) on a rodent model of GBM using CEST MRI to monitor the molecular changes associated with tumor physiology and necrosis. Significant decreases in APT and rNOE signals were detected in the rePDT group as well as decreased proliferative activities in histology when compared with sPDT. This indicates that both APT and rNOE can be a reliable approach to assess PDT treatment efficacy against GBM.

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