Abstract #2998

Quantitative volumetric mapping of intracellular pH in the human brain at 7 T using endogenous CEST-MRI: A proof of principle study

Philip S Boyd¹, Florian Kroh^1,2, Johannes Breitling¹, Vanessa L Franke^1,2, Mark E Ladd^1,2,3, Peter Bachert^1,2, Steffen Goerke¹, and Andreas Korzowski¹

¹Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, ³Faculty of Medicine, University of Heidelberg, Heidelberg, Germany

Synopsis

Keywords: CEST & MT, Molecular Imaging, intracellular pH, guanidyl protons, 7 Tesla

In this study, our method for quantitative pH_i mapping using endogenous CEST-MRI was successfully transferred to examinations of the human brain at B₀=7T. Applicability in vivo was demonstrated in n=3 healthy volunteers, showing an overall median pH_i,CEST of 7.00 and 6.96 for gray and white matter, respectively. In order to proof the plausibility of the presented approach, the obtained pH_i,CEST maps were additionally validated directly in vivo via ³¹P MRSI at 7T, showing an overall median pH_i,31P of 7.02 and 7.01 for gray and white matter, respectively. Consequently, reliable CEST-based pH_i mapping is now also possible in the human brain.

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