Abstract #2999

Intrinsic CSF outflow declines with age in healthy humans detected by spin-labeling MRI

Vadim Malis¹, Won Bae^1,2, Asako Yamamoto³, Linda McEvoy¹, Marin McDonald¹, and Mitsue Miyazaki¹

¹Radiology, University of California, San Diego, La Jolla, CA, United States, ²VA San Diego Healthcare System, San Diego, CA, United States, ³Radiology, Teikyo University, Tokyo, Japan

Synopsis

Keywords: Neurofluids, Aging, cerebrospinal fluid (CSF), intrinsic CSF outflow, egress pathwaysParasagittal dura (PSD) along the superior sagittal sinus (SSS) can be visualized using FLAIR and 3D SSFSE without gadolinium-contrast administration. Visualization of intrinsic CSF outflow from the PSD to the SSS can be achieved in human brains using spin-labeling MRI at clinical 3-T MRI. The spin-labeling MRI shows intrinsically tagged CSF outflow from the upper PSD and lower PSD to SSS. The quantitative intrinsic CSF outflow metrics indicate an age-related decline of the intrinsic CSF outflow at the SSS in human brains.

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