Abstract #3005

Impaired permeability in the choroid plexus in a tauopathy mouse model – a pilot study

Yuhan Bian^1,2,3, Ning Wang⁴, Di Cao^1,2,3, Yuanqi Sun^1,2,3, Chunming Gu^1,2,3, Yinghao Li^1,2,3, Jiangyang Zhang⁵, Peter C.M. Van Zijl^1,2, Xiaobo Mao⁴, and Jun Hua^1,2

¹F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ²Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins, Baltimore, MD, United States, ³Department of Biomedical Engineering, Johns Hopkins, Baltimore, MD, United States, ⁴Department of Neurology, Johns Hopkins, Baltimore, MD, United States, ⁵Center for Biomedical Imaging, NYU Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Neurofluids, Alzheimer's DiseaseThe choroid plexus (CP) is a gateway for the exchange of various metabolites between the microvasculature and brain. Impairment of CP has been reported in various diseases. Recently, dynamic-susceptibility-contrast-in-the-CSF (cDSC) MRI was developed to measure Gd-induced signal changes in the CSF. Here, cDSC MRI was performed with Intraperitoneal Gd-injection in a tauopathy mouse model to examine CP permeability. The maximal Gd-induced signal change was greater in the ventricles in tau mice than WT mice, indicating an increase of Gd leakage from the microvasculature into the ventricles through the CP.

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