Abstract #3006

Investigation of the ALDH2 genetic polymorphism effect in alcohol-related glymphatic dysfunction using DTI-ALPS

Yuichi Morita^1,2, Koji Kamagata¹, Kaito Takabayashi¹, Christina Andica^1,3, Junko Kikuta¹, Shohei Fujita^1,2, Hiroki Tabata⁴, Hitoshi Naito⁵, Yuki Someya^4,6, Hideyoshi Kaga⁵, Toshiaki Akashi¹, Akihiko Wada¹, Yoshifumi Tamura^4,5, Ryuzo Kawamori^4,5, Hirotaka Watada^4,5, Toshiaki Taoka⁷, Shinji Naganawa⁸, Osamu Abe², and Shigeki Aoki¹

¹Department of Radiology, Graduate School of Medicine, Juntendo university, Tokyo, Japan, ²Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ³Faculty of Health Data Science, Juntendo University, Chiba, Japan, ⁴Sportology Center, Graduate School of Medicine, Juntendo university, Tokyo, Japan, ⁵Department of Metabolism & Endocrinology, Graduate School of Medicine, Juntendo university, Tokyo, Japan, ⁶Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan, ⁷Department of Innovative Biomedical Visualization, Graduate School of Medicine, Nagoya University, Aichi, Japan, ⁸Department of Radiology, Graduate School of Medicine, Nagoya University, Aichi, Japan

Synopsis

Keywords: Neurofluids, Diffusion Tensor Imaging, Glymphatic system, DTI-ALPSExcessive alcohol intake seriously damages the brain. Previous animal studies reported that the glymphatic system, which is a brain waste clearance system via the cerebral spinal fluid, is affected by chronic high alcohol consumption. Glymphatic dysfunction is related to cognitive impairment. The changes of diffusivity along the perivascular space (ALPS) indices associated with heavy, moderate, and no‑alcohol intake and executive function with or without aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism was evaluated. The present study revealed the glymphatic function and executive function decline in heavy drinkers. Furthermore, ALDH2 rs671 variants may increase vulnerability to alcohol-induced glymphatic dysfunction.

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