Abstract #3008

Exploring microstructural changes in patients with vascular cognitive impairment using multi-b-value diffusion and T2-relaxometry MRI

Gerhard Drenthen¹, Paulien HM Voorter¹, Maud van Dinther², Julie Staals², Robert J van Oostenbrugge², Walter H Backes¹, and Jacobus FA Jansen¹

¹Department of Radiology & Nuclear Medicine, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, Netherlands, ²Department of Neurology, CARIM School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, Netherlands

Synopsis

Keywords: Neurofluids, Relaxometry, Interstitial fluidLocal increases of interstitial fluid (ISF) predates axonal damage in white matter hyperintensities (WMH). However, it is challenging to disentangle these processes on T2w-MRI. By using multi-b-value diffusion and multi-echo T2-relaxometry imaging, we aimed to quantify markers of ISF volume and mobility in patients with vascular cognitive impairment (VCI) and healthy controls (HC). A trend for a higher mobility and volume of ISF was found in VCI patients compared to HC. Moreover, in VCI, elevated mobility of ISF was already present in perilesional tissue compared to normal-appearing white matter, suggesting that it might be an early marker of WMH development.

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