Abstract #3013

Three-dimensional flow velocity of cerebrospinal fluid (CSF) in human brain during sleep via simultaneous EEG and dynamic sodium MRI

Ying-Chia Lin¹, Xingye Chen¹, Simon Henin^2,3, Nahbila-Malikha Kumbella¹, Liz Aguilera¹, Zena Rockowitz³, Ashley Clayton³, James Babb¹, Yulin Ge¹, Arjun Masurkar^2,3, Anli Liu^2,3, Yvonne W. Lui^1,4, Fernando E. Boada^1,5, and Yongxian Qian¹

¹Department of Radiology, NYU Grossman School of Medicine, New York, NY, United States, ²Department of Neurology, NYU Grossman School of Medicine, New York, NY, United States, ³Department of Neurology, NYU Langone Health, New York, NY, United States, ⁴Department of Radiology, NYU Langone Health, New York, NY, United States, ⁵Department of Radiology, Stanford University, Stanford, CA, United States

Synopsis

Keywords: Neurofluids, Velocity & Flow, Sodium MRI, CSF flow, SleepCerebrospinal fluid (CSF) flow plays a key role in clearance of waste proteins from the brain. Current proton (¹H) MRI is limited to measurement of CSF flow in specific regions such as the aqueduct, due to the lack of capability distinguishing CSF from water. Sodium (²³Na) MRI is uniquely sensitive to CSF, instead of water, and has the potential to measure CSF flow in entire brain. Here, we use a recently-developed dynamic sodium MRI to measure CSF flow velocity in the brain and to understand how it changes with sleep state monitored by MRI-compatible EEG.

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