Abstract #3014

Extracellular Volume Change in the Human Brain During Sleep: Monitored by MRI-Compatible EEG and Measured by Sodium MRI

Xingye Chen¹, Ying-Chia Lin¹, Simon Henin^2,3, Nahbila-Malikha Kumbella¹, Liz Aguilera¹, Zena Rockowitz³, Ashley Clayton³, Shichun Chen⁴, Weiying Dai⁴, James Babb¹, Yulin Ge¹, Arjun Masurkar^2,3, Yvonne W. Lui^1,5, Fernando E. Boada^1,6, Anli Liu^2,3, and Yongxian Qian¹

¹Radiology, NYU Grossman School of Medicine, New York, NY, United States, ²Neurology, NYU Grossman School of Medicine, New York, NY, United States, ³Neurology, NYU Langone Health, New York, NY, United States, ⁴Department of Computer Science, State University of New York at Binghamton, Binghamton, NY, United States, ⁵Radiology, NYU Langone Health, New York, NY, United States, ⁶Radiology, Stanford University, Stanford, CA, United States

Synopsis

Keywords: Neurofluids, Velocity & Flow, MRI-compatible EEG, Sodium MRI, Sleep, Extracellular SpaceSleep is reported in mince studies to increase extracellular space and improve CSF clearance of amyloid beta proteins from the animal brains. However, it is unclear whether sleep also benefits humans. This study used simultaneous MRI-compatible EEG to monitor sleep stage of human study subjects and used sodium MRI to quantify extracellular volume fraction. We seek to find the association between sleep stage and extracellular volume change in the human brain.

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