Abstract #3020

Patients with sickle cell disease have altered brain fractional anisotropy, axial, mean and radial diffusivity quantified by 7T MRI.

Elizabeth Meinert-Spyker¹, Tales Santini², Sharadhi Umesh Bharadwaj¹, Enrico Novelli^3,4,5, Tamer Ibrahim^2,6,7, and Sossena Wood^1,8

¹Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, United States, ²Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, ³Hematology/Oncology, University of Pittsburgh, Pittsburgh, PA, United States, ⁴Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, United States, ⁵Sickle Cell Center of Excellence, University of Pittsburgh, Pittsburgh, PA, United States, ⁶Radiology, University of Pittsburgh, Pittsburgh, PA, United States, ⁷Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States, ⁸Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, United States

Synopsis

Keywords: White Matter, Diffusion Tensor Imaging, Sickle cell diseaseThis abstract compares diffusion tensor imaging parameters between healthy controls and sickle cell disease (SCD) patients. Various softwares were utilized to obtain diffusion metrics and conduct voxelwise comparison was conducted. Fractional anisotropy (FA) and axial diffusivity (AD) values were significantly decreased in patients with SCD compared to controls, while mean diffusivity (MD) and radial diffusivity (RD) were primarily increased in patients compared to controls. Our FA and MD findings are consistent with other studies comparing diffusion metrics of individuals with SCD at a lower magnet field. We also present novel findings comparing AD and RD values for the SCD population.

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