Abstract #3022

Evidence of diffusion tensor imaging measures of white matter microstructure changes within six months after stroke

Stefan E. Poirier^1,2, Jonathan D. Thiessen^1,2, Alexander V. Khaw^1,3, and Udunna C. Anazodo^1,2,3,4

¹Lawson Imaging, Lawson Health Research Institute, London, ON, Canada, ²Department of Medical Biophysics, Western University, London, ON, Canada, ³Department of Clinical Neurological Sciences, Western University, London, ON, Canada, ⁴Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada

Synopsis

Keywords: White Matter, Diffusion Tensor ImagingWhite matter (WM) damage is associated with post-stroke cognitive impairment. In this study, we used diffusion tensor imaging (DTI) to investigate changes in WM microstructure in patients within 6-months following stroke. Quantitative DTI measurements were compared in patients at 6-months relative to 4-weeks post-stroke. DTI showed signs of reduced WM integrity in several WM tracts, including rostrum of corpus callosum and superior longitudinal fasciculus III in patients 6-months post-stroke. In elderly adults, WM microstructure can be disrupted following ischemic stroke. These findings motivate larger population stroke studies using advanced diffusion MRI techniques to further assess WM structure in stroke patients.

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