Keywords: White Matter, Phantoms, Monte Carlo simulations for microstructure in DW-MRIInferring microscopic tissue properties from the measured signal is one of the main objectives of diffusion-weighted magnetic resonance imaging. The use of Monte-Carlo Simulations for DW-MRI on realistic substrates will help the study of DWI-MRI signals in controlled environments and investigate, extract, and validate approaches for the understanding of white matter features. This work provides a unique framework for building complex white matter phantoms with novel properties, such as 1) substrates with a high packing density of 95% intra-axonal volume percentage and substrate sizes of (500 um)3, 2) Create, generalise, extend, and preexisting phantom configurations used by other studies.
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