Keywords: White Matter, Diffusion Tensor Imaging, Deep brain stimulationWe found that the location of the ventral intermediate nucleus (Vim) as determined with dMRI tractography differed only 0.92 mm on average on subsequent scans within the same individual (SD: 0.51 mm) in a test-retest study of 29 healthy individuals. The difference with a commonly used manual method that locates the Vim at fixed distances in relation to the commissures and third ventricular wall was more pronounced: on average 2.44 mm (SD: 0.92 mm). We believe that dMRI tractography based DBS target determination seems feasible and rather accurate, given that acquisition parameters and post-processing are optimal.
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