Abstract #3030

Differences in cerebellar fiber tract dispersion in coronary artery disease patients are associated with episodic memory and processing speed

Stefanie A Tremblay^1,2,3, Dalia Sabra^1,2,3,4, Safa Sanami^1,2, Ali Rezaei^1,2, Zacharie Potvin-Jutras^1,2, Christine Gagnon², Brittany Intzandt⁵, Amélie Mainville-Berthiaume⁶, Lindsay N Wright^1,2, Dajana Vuckovic⁷, Josep Iglesies-Grau^2,8, Thomas Vincent², Mathieu Gayda², Anil Nigam², Louis Bherer^2,8,9, and Claudine J Gauthier^1,2,3

¹Physics, Concordia University, Montreal, QC, Canada, ²Centre ÉPIC and Research Center, Montreal Heart Institute, Montreal, QC, Canada, ³PERFORM Centre, Concordia University, Montreal, QC, Canada, ⁴Department of Biomedical Science, Université de Montreal, Montreal, QC, Canada, ⁵BrainLab, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada, ⁶Psychology, Concordia University, Montreal, QC, Canada, ⁷Department of Chemistry and Biochemistry, Concordia University, Montreal, QC, Canada, ⁸Department of Medicine, Université de Montreal, Montreal, QC, Canada, ⁹Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, QC, Canada

Synopsis

Keywords: White Matter, Diffusion/other diffusion imaging techniques, DTI, NODDIHere we characterized the impact of coronary artery disease (CAD) on the brain’s white matter (WM) using diffusion tensor (DTI) and neurite orientation dispersion and density imaging (NODDI). Mean diffusivity was higher in CAD patients in occipital WM and there were differences in orientation dispersion in several tracts between CAD patients and healthy controls. Alterations in fiber dispersion of cerebellar WM were associated with global cognition, episodic memory, and processing speed. Our study supports the use of advanced diffusion imaging models for the early detection of subtle WM damage in populations at risk of developing dementia such as CAD patients.

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