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Abstract #3036

Neural correlates of anxiety in rhesus macaques exposed to early social adversity: A longitudinal DTI study across adolescence.

Hind Errame1,2, Holly Rayson1,2, Alice Massera1,2, Yann Bihan-Poudec1,2, Franck Lamberton3, Mathilda Froesel1,2, Maeva Gacoin1,2, Suliann Ben Hamed1,2, Nathalie Richard1,2, Pier-Francesco Ferrari1,2, and Bassem Hiba1,2
1Institut des sciences cognitives Marc Jeannerod (ISC) , CNRS, LYON, France, 2Claude Bernard University, Lyon 1, LYON, France, 3CERMEP - Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant, LYON, France

Synopsis

Keywords: White Matter, Diffusion Tensor Imaging

Using diffusion tensor imaging (DTI) and behavioral observation, this study investigated the longitudinal effects of early social adversity (ESA) on risk for anxiety and the neural mechanisms underlying this relationship across adolescence.

Diffusion MRI data were collected from 21 macaques comprising two groups that differed in exposure to ESA; mother-reared and nursery-reared. Each monkey was scanned at 2.5, 3.5 and 4.5 years old, with anxiety-like behavior assessed at each time-point.

Results suggest that ESA has long-term effects on WM fractional anisotropy (FA) in several regions, with differences in frontolimbic and frontostriatal WM tracts modulating the relationship between ESA and anxiety .

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Keywords