Abstract #3038

Comparison of High-Frequency Conductivity in the Brains of Alzheimer’s Disease Patients and Cognitively Normal Elderly Controls

Geon-Ho Jahng¹, Soonchan Park¹, Sue Min Jung², Mun Bae Lee³, Hak Young Rhee⁴, Chang-Woo Ryu¹, A- Rang Cho⁵, and Oh In Kwon³

¹Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, ²Biomedical Engineering, Kyung Hee University, Yongin-si, Korea, Republic of, ³Mathematics, Konkuk University, Seoul, Korea, Republic of, ⁴Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, ⁵Psychiatry, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of

Synopsis

Keywords: Alzheimer's Disease, Electromagnetic Tissue PropertiesThe objective of this study was to investigate high-frequency conductivity (HFC) obtained using magnetic resonance electrical property tomography (MREPT) in participants with Alzheimer’s disease (AD), amnestic mild cognitive impairment (MCI), and cognitively normal (CN) elderly controls. High-frequency conductivity (HFC) values in the brain are significantly increased in Alzheimer’s disease (AD) patients compared to cognitively normal (CN) elderly people, are negatively associated with Mini-Mental State Examination (MMSE) scores, and therefore can be used as an imaging biomarker to improve the differentiation of AD from CN.

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