Abstract #3039

Comparison of diffusion kurtosis tensor imaging and multi-tissue CSD for the investigation of group differences in Alzheimer’s disease

Diana L. Giraldo^1,2,3, Robert E. Smith⁴, Hanne Struyfs⁵, Ellis Niemantsverdriet⁵, Ellen De Roeck⁵, Sebastiaan Engelborghs⁵, Eduardo Romero², Jan Sijbers^1,3, and Ben Jeurissen^1,3,6

¹imec-Vision Lab, University of Antwerp, Antwerp, Belgium, ²Computer Imaging and Medical Applications Laboratory - Cim@Lab, Universidad Nacional de Colombia, Bogota, Colombia, ³µNEURO Research Center of Excellence, University of Antwerp, Antwerp, Belgium, ⁴The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, ⁵Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium, ⁶Lab for Equilibrium Investigations and Aerospace, University of Antwerp, Antwerp, Belgium

Synopsis

Keywords: Alzheimer's Disease, Data AnalysisIn this work, we compare the results of analyzing group differences in Alzheimer’s Disease (AD) with two different models for multi-shell diffusion MRI: the Diffusion Kurtosis Tensor (DKT) and Multi-Tissue Constrained Spherical Deconvolution (MT-CSD). Separate analysis for DKT metrics and measures derived from MT-CSD were performed to investigate differences between control subjects and patients with mild cognitive impairment and dementia due to AD. Statistical analyses included strong family-wise error correction for multiple comparisons. Results indicate that analyses with MT-CSD capture the differences that are detectable with DKT while offering more specific details that facilitate the interpretation of those differences.

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