Keywords: Alzheimer's Disease, Gray Matter, structural covariance networkWe aimed to investigate whether spatial navigation could reveal subcortical structural alterations and the risk of clinical progression in subjective cognitive decline (SCD). SCD subjects were divided into SCD-good (G-SCD) and SCD-bad (B-SCD) groups according to their navigation performance. The B-SCD group showed decreased volumes in the basal forebrain and had a larger shortest path length in the subcortical structural covariance network than the G-SCD group. Follow-up data suggested that the B-SCD group had a higher conversion rate to MCI than the G-SCD group. This study may provide new insights for the risk assessment and early intervention for SCD subjects.
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