Abstract #3042

Functional connectivity to entorhinal cortex in hypertensive Alzheimer’s disease rat models

Yi Chen^1,2, Zachary Fernandez^3,4, Norman Scheel³, Mahsa Gifani⁵, Chunqi Qian³, Anne M. Dorrance⁶, Scott E. Counts^4,5,7,8, and David C. Zhu³

¹Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ²Department of Radiology, Michigan State University, East Lansing, MI, United States, ³Department of Radiology and Cognitive Imaging Research Center, Michigan State University, East Lansing, MI, United States, ⁴Neuroscience Program, Michigan State University, East Lansing, MI, United States, ⁵Department of Translational Neuroscience, Michigan State University, Grand Rapids, MI, United States, ⁶Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, United States, ⁷Department of Family Medicine, Michigan State University, Grand Rapids, MI, United States, ⁸Hauenstein Neurosciences Center, Mercy Health Saint Mary’s Hospital, Grand Rapids, MI, United States

Synopsis

Keywords: Alzheimer's Disease, AnimalsExtensive studies have revealed that the entorhinal cortex (EC) plays a critical role in Alzheimer’s disease (AD) development. However, EC functional connectivity and its associated network abnormalities are understudied, especially in rodent models. To the best of our knowledge, this is the first study to report disrupted EC functional connectivity in hypertensive AD rodents using resting-state fMRI. Our results may provide new insights into the impaired EC connectivity patterns and enable the search for novel preclinical EC-based fMRI biomarkers for AD studies. In addition, our novel animal model provides new information to understand the link between hypertension and AD.

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