Abstract #3048

White matter damage in end-stage kidney disease patients with cognitive impairment: a fixel-based analysis

Chih-Chien Tsai¹, YI-Chou Hou², Yao-Liang Chen³, and Jiun-Jie Wang⁴

¹Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan, ²Department of Nephrology, Cardinal Tien Hospital at Xindian, New Taipei City, Taiwan, ³Department of Diagnostic Radiology, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan, ⁴Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan

Synopsis

Keywords: Dementia, KidneyPatients with end-stage kidney disease are vulnerable to cognitive impairment or dementia. Previous studies indicated that end-stage kidney disease subjects manifest prominent white matter hyperintensities. We use fixel-based analysis to examine the tract-specific differences in fixel-based metrics between end-stage kidney disease patients and normal participants. The results demonstrate the pattern of white matter degeneration in end-stage kidney disease patients. Our findings suggest that end-stage kidney disease patients with cognitive impairment exhibit white matter abnormalities. In clinical, the fixel-based analysis may serve as a potential biomarker for monitoring white matter change caused by disease.

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