Keywords: Alzheimer's Disease, fMRI (resting state)The default mode network (DMN) could be further divided into three subsystems, and each subsystem of DMN serves different cognitive functions. In this study, we revealed that cognitive decline is driven by weakened functional connectivity within the core subsystems, but enhanced functional connectivity between the core and MTL subsystems as well as the core and DMPFC subsystems. This dissociation may reflect abnormal core-centered connection abnormalities, along with the disruption of the MTL subsystem and the DMPFC subsystem to some degree. Our findings provided a promising imaging biomarker for the early diagnosis of AD.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords