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Abstract #3057

Cortical Blood Perfusion during Preclinical Migraine at 21.1 T using FAIR-PASL

Dayna Leigh Richter1,2 and Samuel Colles Grant1,2
1National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 2Chemical & Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL, United States

Synopsis

Keywords: Neurodegeneration, Arterial spin labelling, Migraine, FAIR-EPIMigraine is a neurological disorder with neurovascular implications. Blood flow changes based on brain's activity and needs, so excessive neural activation during migraine is likely to make significant alterations to cortical blood perfusion. Therefore, cortical blood perfusion was measured using FAIR-PASL to monitor the progression in preclinical migraine in female Sprague-Dawley rats. Parameters for inversion RF pulse shape and slice thickness were optimized to achieve more robust fits for monitoring cortical blood perfusion during preclinical migraine.

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Keywords