Abstract #3061

Assessing cerebral perfusion: transfer function analysis of the BOLD response to hypoxia-induced changes in deoxyhemoglobin

James Duffin^1,2, Ece Su Sayin^1,3, Olivia Sobczyk^2,3, Julien Poublanc⁴, Harrison T. Levine^1,3, David J. Mikulis⁴, and Joseph A. Fisher^1,5

¹Physiology, University of Toronto, Toronto, ON, Canada, ²Department of Anaesthesiology and Pain Management, University of Toronto, Toronto, ON, Canada, ³Joint Department of Medical Imaging and the Functional Neuroimaging Lab,, University Health Network, Toronto, ON, Canada, ⁴Joint Department of Medical Imaging and the Functional Neuroimaging Lab, University Health Network, Toronto, ON, Canada, ⁵Department of Anaesthesiology and Pain Management, University Health Network, Toronto, ON, Canada

Synopsis

Keywords: Data Analysis, Brain

We used hypoxia-induced changes in deoxyhemoglobin concentration as a susceptibility contrast agent. Transfer function analysis of the resulting changes in the BOLD signal for each voxel provided cerebral perfusion measures that indicate the distribution of the strength of the signal response to the contrast agent (gain) and the lag of the response (phase or time). We relate the gain and lag to conventional resting hemodynamic measures cerebral blood volume and mean transit time, respectively.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.