Abstract #3065

Intracranial Wall Permeability for Prediction of Aneurysm Growth Using Dynamic Contrast-Enhanced MRI

Ziming Xu¹, Linggen Dong², Longhui Zhang², Yajie Wang¹, Jiaqi Dou¹, Peng Liu², Ming Lv², and Huijun Chen¹

¹Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing, China, ²Department of Neurosurgery, Beijing Tiantan Hospital, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China

Synopsis

Keywords: Data Analysis, DSC & DCE PerfusionSize of intracranial aneurysm (IA) is considered the most important clinical factor to determine the risk of IA rupture. Accurate prediction of aneurysm growth is crucial for preventive management but remains challenging. Herein, we studied the potential predictive roles of demography and imaging characteristics in a radiological follow-up study. And wall permeability calculated by DCE-MRI was firstly observed to accurately identify the IAs with a relatively high risk of aneurysm growth (AUC = 0.875). Our study demonstrated that higher wall permeability was associated with aneurysm growth and the regions with higher wall permeability co-localized with the direction of aneurysm growth.

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