Abstract #3074

Reliable blood-brain barrier water exchange estimates in the rat brain using a crusher-compensated exchange rate (CCXR) model

Yolanda Ohene^1,2, Elizabeth Powell³, Samo Lasič^4,5, Geoff J. M. Parker^3,6, Laura M. Parkes^1,2, and Ben R. Dickie^2,7

¹Division of Psychology, Communication and Human Neuroscience, University of Manchester, Manchester, United Kingdom, ²Geoffrey Jefferson Brain Research Centre, University of Manchester, Manchester, United Kingdom, ³UCL, London, United Kingdom, ⁴Danish Research Centre for Magnetic Resonance, Copenhagen, Denmark, ⁵Random Walk Imaging, Åkarp, Sweden, ⁶Bioxydyn Limited, Manchester, United Kingdom, ⁷Division of Informatics, University of Manchester, Manchester, United Kingdom

Synopsis

Keywords: Data Processing, PermeabilityFilter exchange imaging (FEXI) is a promising technique for measuring water exchange across the blood-brain barrier (BBB). However, the application of FEXI for the rodent brain requires thinner slices and therefore higher crusher gradients which lead to a progressive underestimation of the apparent exchange rate (AXR). Here, we implement a crusher-compensated exchange rate (CCXR) model which reduces the bias induced by the crusher gradients and allows more accurate estimates of BBB water exchange in the rat brain.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.