Abstract #3093

High temporal resolution DCE-MRI improves the performance of model fitting parameters

Xin Li¹, Travis Rice-Stitt², Lina Gao³, Marina Aguiñaga⁴, Kevin R Turner⁵, Bryan Foster⁶, Fergus Coakley⁶, Mark Garzotto^4,7, and Ryan Kopp^4,7

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Pathology, Oregon Health & Science University, Portland, OR, United States, ³Knight Biostatistics Shared Resources, Oregon Health & Science University, Portland, OR, United States, ⁴Urology, Oregon Health & Science University, Portland, OR, United States, ⁵Providence Health and Service, Portland, OR, United States, ⁶Diagnostic Radiology, Oregon Health & Science University, Portland, OR, United States, ⁷Portland VA Medical Center, Portland, OR, United States

Synopsis

Keywords: Data Analysis, DSC & DCE PerfusionRecent advance in data acquisition makes fast DCE-MRI data acquisition feasible. This work investigated the impact of DCE-MRI temporal resolution on the data’s pharmacokinetic modeling and the water exchange effect imparted into the model parameters. Using both the Tofts model and the water-exchange sensitized Shutter-Speed model, our results showed that DCE data with higher temporal resolution (shorter intersample interval) is beneficial in model parameter precision and in quantifying transcytolemmal water exchange effect. The later may offer additional lesion-detection specificity in clinical prostate MRI.

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