Abstract #3116

Improving the accuracy of Multipool-Lorentzian fitting in CEST MRI by use of a Pseudo-Voigt lineshape for direct water saturation

Markus Huemer¹, Clemens Stilianu¹, and Rudolf Stollberger^1,2

¹Institute of Biomedical Imaging, Graz University of Technology, Graz, Austria, ²BioTechMed Graz, Graz, Austria

Synopsis

Keywords: Data Analysis, CEST & MTIn Chemical Exchange Saturation Transfer (CEST) MRI one common analysis technique is Multipool-Lorentzian fitting of the resulting Z-Spectrum. Multiple Lorentzian lineshapes are fitted to the measured data. The lineshape of the direct water saturation (DS) can deviate substantially from a Lorentzian depending on the saturation scheme and $$$B_1^+$$$. To prevent a cross-influence of the DS on the CEST and increase the fit accuracy we propose the use of a Pseudo-Voigt lineshape for the water line.

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