Abstract #3119

Tract-specific myelin mapping using magnetization transfer-prepared diffusion imaging: comparison with conventional MTR tractometry

Wen Da Lu^1,2, Mark Cameron Nelson^2,3, Ilana Ruth Leppert², Pietro Bontempi⁴, Simona Schiavi^4,5, Christopher Dennis Rowley^1,2, Alessandro Daducci⁴, and Christine Lucas Tardif^1,2,3

¹Department of Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada, ²McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, Montreal, QC, Canada, ³Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, ⁴Department of Computer Science, University of Verona, Verona, Italy, ⁵Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genova, Italy

Synopsis

Keywords: Data Analysis, Tractography & Fibre Modelling, Magnetization Transfer, Diffusion-Weighted Imaging, TractometryTractometry is a technique used to investigate the microstructure variations along white matter tracts or to reconstruct microstructure-weighted connectivity matrices. However, partial volume effects from crossing fibers bias the individual fiber measurements and conceal subtle differences. Here, we compare MTR tractometry to a novel approach using dual-encoded MT-weighted DWI analyzed using COMMIT to disentangle the MTR signal of individual white matter fibers. The results show a broader distribution in edge MTR values for the dual-encoding approach in comparison to tractometry. Both techniques show similar spatial MTR patterns, however the dual-encoded MT-weighted DWI approach shows a higher pattern of inter-individual variability.

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