Abstract #3124

Subject-specific analysis reveals spatially heterogeneous white matter abnormalities in sports-related concussion

Ho-Ching Yang¹, Mario Dzemidzic^1,2, Qiuting Wen¹, Larry D Riggen Jr³, Steven P Broglio⁴, Michael A McCrea⁵, Thomas W McAllister⁶, Jaroslaw Harezlak⁷, and Yu-Chien Wu^1,8

¹Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, ²Department of Neurology, Indiana University School of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States, ³Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, India, ⁴Michigan Concussion Center, University of Michigan, Ann Arbor, MI, United States, ⁵Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, ⁶Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States, ⁷Department of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, IN, United States, ⁸Stark Neurosciences Research Initiative, Indiana University School of Medicine, Indianapolis, IN, United States

Synopsis

Keywords: Data Analysis, Traumatic brain injury, Subject-specific analysis, Heterogeneous, ConcussionSport-related concussion (SRC) injury inclines to cause subject-specific brain region abnormalities. This study applied subject-specific analysis that accounts for inter-subject variation to investigate heterogeneity of white matter alterations in a sample from a large national multicenter study, the Concussion Assessment, Research and Education Consortium. Our results demonstrated that subject-specific white matter abnormalities in SRC can be uncovered by calculating the extreme Z-score maps based on a template generated from normally distributed diffusion tensor imaging metric values in non-contact sports controls. Our finding indicates that the SRC-induced white matter abnormalities show heterogeneous spatial distribution across participants.

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