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Abstract #3131

Diaphragm Excursion Measured by Free-breathing 1H MRI in Patients with Asthma: Repeatability and Bronchodilator Response

Yonni Friedlander1,2, Dante P.I. Capaldi3, Norm Konyer1, Melanie Kjarsgaard2, Carmen Venegas2,4, Parameswaran Nair2,4, and Sarah Svenningsen1,2,4
1Imaging Research Centre, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 2Firestone Institute of Respiratory Health, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 3Deparment of Radiation Oncology, University of California San Francisco, San Francisco, CA, United States, 4Division of Respirology, McMaster University, Hamilton, ON, Canada

Synopsis

Keywords: Data Analysis, LungUsing free-breathing 1H MRI, diaphragm excursion was measured in 9 patients with severe asthma at two visits 4-months apart. At each visit, patients with asthma were imaged before and after administration of a bronchodilator. Diaphragm excursion measured at the two visits were not significantly different from one another (mean bias=0.34cm, p=0.07) and were well correlated (r=0.53, p=0.004), demonstrating repeatability of the measurement. In addition, diaphragm excursion was significantly increased following bronchodilator administration (p=0.01).

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