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Abstract #3139

Change in ATP flux after propionate ingestion in healthy volunteers Using 31P MRS Saturation Transfer.

Abi Spicer1, Stephen Bawden1,2, Penny Anne Gowland1, Susan Francis1, Douglas Morrison3, Guruprasad Aithal4, and Gary Frost5
1University of Nottingham, Nottingham, United Kingdom, 2NIHR Nottingham Biomedical Research Centre, Nottingham University hospitals NHS trust, Nottingham, United Kingdom, 3Scottish Universities Environmental Research Centre (SUERC), University of Glasgow, Glasgow, United Kingdom, 4Nottingham Biomedical Research Centre NUH, University of Nottingham, Nottingham, United Kingdom, 5Section for Nutrition, Faculty of Medicine, Imperial College London, London, United Kingdom

Synopsis

Keywords: Liver, Spectroscopy, Multinuclear

Propionate is a short chain fatty-acid absorbed in the colon and metabolised in the liver with some evidence showing that consumption can increase energy homeostasis. Three healthy participants have been studied to date with 31P saturation transfer experiments performed pre and 180 minutes post consumption of an inorganic-propionate ester using 1D-slice-selective-ISIS. The exchange rate constant (k) was calculated to be higher than previous studies despite similar methodologies. Whilst at this time no conclusions can be drawn about the effect of consuming Inorganic Propionate Ester thus far, this study shows the applicability of using 31P saturation transfer in simpler intervention studies.

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