Abstract #3142

Pharmacokinetic Modelling of Gd-EOB-DPTA Uptake: Early Progression of NASH in A Clinically Relevant Cohort, at 1.5 and 3 T

Christian Simonsson^1,2,3, Nils Dahlström^1,3, Markus Karlsson¹, Shan Cai¹, Simone Ignatova⁴, Patrik Nasr⁵, Mattias Ekstedt^3,5, Stergios Kechagias^3,5, and Peter Lundberg^1,3

¹Department of Radiation Physics, Radiology, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, ²Department of Biomedical Engineering, Linköping University, Linköping, Sweden, ³Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, ⁴Department of Clinical Pathology and Clinical Genetics, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden, ⁵Department of Gastroenterology and Hepatology, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden

Synopsis

Keywords: Liver, Contrast Agent, NAFLD,NASH, Gd-DPTA-EOB, Pharmacokinetic ModelingDue to the increased global prevalence of non-alcoholic fatty liver disease (NAFLD), there is a significant need for precise and non-invasive clinical methods to detect early stages of non-alcoholic steatohepatitis (NASH), which can progress to cirrhosis. We investigate the possibility of using the hepatocyte specific contrast agent Gd-EOB-DPTA based DCE-MRI in combination with mathematical modelling to assess hepatobiliary influx, as a possible biomarker for early NASH detection. We show a tentative correlation between increased portal inflammation and decreased hepatic Gd-EOB-DPTA uptake in a cohort of prospectively included patients with suspected chronic liver disease.

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