Abstract #3160

Comparison of pH-weighted and conventional MRI signal in ischemic stroke

Tao Jin¹, Jicheng Wang², T. Kevin Hitchens³, Dandan Sun⁴, Andriy Bandos⁵, Joseph Mettenburg¹, Ping Wang¹, and Julius Juhyun Chung¹

¹Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States, ²Department of Urology, University of Pittsburgh, Pittsburgh, PA, United States, ³Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, United States, ⁴Department of Neurology, University of Pittsburgh, Pittsburgh, PA, United States, ⁵Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, United States

Synopsis

Keywords: CEST & MT, Stroke, APT, PenumbraThe sensitivity of APT MRI in the evaluation of ischemic tissue status was evaluated in stroke rat brains and compared with conventional MRI methods. APT can detect the different levels of tissue acidosis in the ischemic core, penumbra, and oligemia regions. Additionally, APT can also differentiate the severity of tissue acidosis associated with different blood glycemic levels. Our results indicate that APT MRI is a sensitive pH-weighted imaging marker with great potential for the evaluation of the ischemic tissue status and prediction of the stroke outcome.

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