Abstract #3161

Simultaneous mapping of glycogen and phosphocreatine in human skeletal muscle by saturation transfer MRI

Chongxue Bie^1,2, Chao Zhou¹, Peter C. M. van Zijl^3,4, Nirbhay N. Yadav^3,4, Yin Wu¹, Hairong Zheng¹, and Yang Zhou¹

¹Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²Department of Information Science and Technology, Northwest University, Xi’an, China, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁴The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: CEST & MT, MetabolismGlycogen and phosphocreatine (PCr) are essential metabolites for maintaining cellular ATP levels. Recent reports show the possibility of PCr mapping in skeletal muscle using CEST MRI but glycogen levels measured using this approach have been inconclusive. Here we report the high-resolution mapping of glycogen and PCr in human skeletal muscle based on relayed nuclear Overhauser effects (glycoNOE) and CEST, respectively. Results at 5T show homogeneous distributions of glycogen and PCr in the calf at levels corresponding to biopsy. Exciting possible applications include localized studies of cellular energetics and noninvasive in situ evaluation of exercise and muscle metabolism in humans.

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