Abstract #3162

The impact of motion and motion correction in dynamic glucose enhanced MRI

Patrick M. Lehmann¹, Christos Papageorgakis², Stefano Casagranda², Anina Seidemo¹, Xiang Xu^3,4, Nirbhay N. Yadav^4,5, Xu Li^4,5, Ronnie Wirestam¹, Patrick Liebig⁶, Frederik Testud⁷, Pia C. Sundgren^8,9,10, Peter C.M. Van Zijl^4,5, and Linda Knutsson^1,4,5

¹Medical Radiation Physics, Lund University, Lund, Sweden, ²Department of R&D Advanced Applications, Olea Medical, La Ciotat, France, ³BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁶Siemens Healthcare GmbH, Erlangen, Germany, ⁷Siemens Healthcare AB, Malmö, Sweden, ⁸Department of Radiology, Lund University, Lund, Sweden, ⁹Lund University Bioimaging Centre, Lund University, Lund, Sweden, ¹⁰Department of Medical Imaging and Physiology, Skane University Hospital, Lund, Sweden

Synopsis

Keywords: CEST & MT, Motion CorrectionDynamic glucose-enhanced (DGE) MRI is a dynamic chemical exchange saturation transfer (CEST) method that can provide information about D-glucose uptake in tissue. DGE signal changes are small and so-called pseudo-DGE effects can appear as true DGE effects. In this study, we investigated how motion and motion correction influenced the DGE effects using both a realistic (measured) motion pattern and an arbitrary motion pattern. We observed that pseudo-DGE effects are governed by the head motion pattern and originate either from tissue mixing at tissue interfaces or B₀-shifts. Although motion correction can reduce these effects, new pseudo-DGE effects can also be introduced.

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